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KMID : 1149220060140020045
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Korean Journal of Oriental Medical Prescription
2006 Volume.14 No. 2 p.45 ~ p.56
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Anti-hyperlipidemia Effect of Gyeongshingangjeehwan (GGEx) in High Fat induced Obese Male Micro-pigs
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Yang Yoo-In
Jung Yang-Sam
Lee Hee-Young
Rhee Sang-Dal
Kim Byoung-Chul
Kim Jong-Hoon
Seok Hoa-Jun
Yoo Jae-Sang
Yoon Ki-Hyeon
Jo Ju-Heum
Kim Hoon
Kim Gyeong-Cheol
Shin Soon-Shik
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Abstract
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Objectives : We evaluated anti-hyperlipidemia effect of Gyeongshinganjeehwan (GGEx) in high fat induced obese male micro-pigs.
Methods : 7 month-old micro-pigs are fed with normal (n = 3) or high fat diet (n = 18) for 12 weeks. The pig revealed obesity in high fat diet were divided into 2 groups (n = 5 each) and vehicle (OMP) and Gyeongshingangjeehwan (GGEx, 616.7 mg/kg/day) were administrated for 1 month. We monitored the changes in body weight and measured plasma cholesterol, triglyceride, free fatty acid, GOT and, GPT after 1 month. The visceral fat were measured with computerized tomography and weights of various organs were measured after sacrifice.
Results : 1. GGEx group had significantly reduced body weight gain than obese control group in statistics. 2. GGEx group didn’t significantly differ from obese control group in blood total cholesterol, blood LDL-cholesterol, blood triglyceride. but it’s data were similar to normal control group. 3. GGEx group had prominantly reduced visceral fat than obese control group in computerized tomography. 4. Blood GOT and GPT didn’t differ from between groups. The organ weight were not significant different. And it is normal in size and colour of visceral organs.
Conclusions : It is concluded that GGEx has anti-hyperlipidemia effect by improving visceral fat and access to security.
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KEYWORD
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obese micro-pigs, Gyeongshingangjeehwan(GGEx), hyperlipidemia, triglyceride
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